Seroprevalence of Human Cytomegalovirus Among Voluntary Blood Donors In Chennai

نویسنده

  • Arun R
چکیده

Background: Human Cytomegalovirus (CMV) is one of the most significant pathogens infecting immunosuppressed individuals. CMV is known to be a significant cause of morbidity and mortality following blood transfusion in immunocompromised individuals. The immunosuppressed population for whom CMV free blood products are requested is increasing due to advances in medical care. The most effective way to minimize the risk of CMV transmission in high risk recipients would be to administer CMV free blood products. The study was performed to find out the seroprevalence of Human CMV among voluntary blood donors in Chennai. Materials and methods: A total of 580 voluntary blood donors were tested for IgM and IgG anti-CMV antibodies by ELISA technique and seronegative samples were confirmed by Polymerase Chain Reaction (PCR). Demographic details and laboratory results were analyzed. Results: Among the 580 donors, 441 (76.03%) were males and 139 (23.97%) were females. It was found that 550 donors were positive for IgG anti-CMV antibody giving an IgG seroprevalence rate of 94.82%. IgM anti-CMV antibody was negative in all the donors. None of the IgG seronegative blood samples were found to contain CMV DNA by PCR. Conclusion: Human CMV is highly prevalent and is a threat to the safety of blood transfusion. Considering the fact that IgM antibody positive donors seldom found, screening for IgM anti-CMV antibody may be practiced only for high risk recipients. Other preventive strategies like leukoreduction or pathogen inactivation can be made available to prevent CMV transmission.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The study of seroprevalence of human cytomegalovirus in healthy blood donors referring to Fars blood bank

Introduction: Human cytomegalovirus (HCMV) infection is most often asymptomatic in immuno-competent individuals and has lifelong latency especially in leukocytes. However, CMV is a major cause of infection and death in immuno-compromised patients. Transfusion transmitted HCMV (TT-HCMV) can cause serious morbidity and mortality in certain patients who are at risk. In this study, we evaluated t...

متن کامل

Evaluation of the Seroprevalence of Transfusion Transmissible Infections among Blood Donors in a Tertiary Care Hospital of North India

Background: Unsafe transfusion practices put patients at high risk of transfusion transmissible infections. We aimed to evaluate the prevalence of transfusion transmissible infections (including Human Immunodeficiency Virus [HIV] 1 and 2, Hepatitis B Virus [HBV], Hepatitis C Virus (HCV) and syphilis) during a period of 18 months among blood donors in the Blood Bank of Lady Hardinge Medical Coll...

متن کامل

Meta-analysis of cytomegalovirus seroprevalence in volunteer blood donors and healthy subjects in Iran from 1992 to 2013

Objective(s):Human cytomegalovirus (CMV), a double-strand DNA herpesvirus, can be transmitted via blood transfusion which is especially important for immunocompromised recipients and can cause a fatal infection. CMV seroprevalence in Iran was studied on blood donors, healthy subjects, and some patients. Highly variable rates were detected. The purpose of this study was to review CMV seroprevale...

متن کامل

Seroprevalence of cytomegalovirus among voluntary blood donors in Delhi, India.

Cytomegalovirus (CMV) is known to be a significant cause of morbidity and mortality following blood transfusion in children and immunocompromised adults. In India, it is not mandatory to screen donated blood for CMV in blood banks. Very few studies have been conducted in India to estimate the seroprevalence of this infection in voluntary blood donors. This study was conducted to estimate the se...

متن کامل

Seroprevalence of Cytomegalovirus Infection in Blood Donors in Khorramabad

Background and Aims: Cytomegalovirus (CMV) has worldwide distribution, and its prevalence rate depends on factors such as economic and geographical conditions. An important way of the virus transmission is via blood. Due to high prevalence of anti-CMV antibodies in blood donors and lack of data concerning its seroprevalence in the region, this study was carried out to determine the prevalence r...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012